NSAIDs work by stopping the production of prostaglandin’s. Prostaglandin’s are a natural chemical in the body that trigger pain. They also reduce inflammation. NSAIDs include aspirin, ibuprofen, naproxen and ketoprofen. Gastrointestinal problems are the most common side effect of NSAIDs. NSAIDs also cause problems with kidney function. The severity and chance of experiencing side effects increase with use. NSAIDs can also interfere with blood pressure medications. People who drink more than 1 alcoholic beverage per week increase their chances of experiencing side effects from NSAIDs.
Acetaminophen works to relieve pain and reduce fever. Acetaminophen works by stopping pain in the brain as opposed to how NSAIDs stop pain at the area of pain. So instead of stopping the pain, acetaminophen actually blocks the brain from feeling the pain. Long term use of acetaminophen, especially in large doses can cause kidney damage. Acetaminophen is easier on the gastrointestinal area than NSAIDs, but can effect the liver with long term use.
Both NSAIDs and acetaminophen may be used together to treat pain. However, it is important not to use two products from the same group together, such as aspirin and naproxen. This could result in an overdose. It is also important to speak with your doctor before taking an over the counter pain medication if you are taking other medication.