Breast Milk Can Provide Protection Against Infections

Jun 06, 2019 Kayode Oseh

Mothers can transfer life-long protection against infection to their infants by breastfeeding. This was the finding from new research in mice by an international team of scientists led by researchers at the University of Cape Town (UCT).

Previously it was generally thought that immunity against illness is passed from mum to baby for only the period they are breastfed, and this protection ends when breastfeeding stops. It was also thought that this immunity was transferred by a mother's proteins such as antibodies that are used by the immune system to neutralize bacteria and viruses.

However, research have found that the transfer of immunity can be long-term, beyond the period of breastfeeding. They also found that this protection was driven by the transfer of immune cells and was completely independent of antibodies.

The research found that infant mice breastfed by a mother who had a worm infection before getting pregnant acquired life-long protection against this infection.Unexpectedly, this effect was passed onto the infants by cells in the mother's milk and not proteins such as antibodies. These transferred cells provided protection from worm infection throughout the body to the infant. This work shows that mothers exposed - even before pregnancy - to a globally prevalent source of infection provides long-term breastfeeding acquired immunity to infection in infants.

Lead Researcher, Dr William Horsnell, from UCT's Institute of Infectious Disease and Molecular Medicine and the Division of Immunology said:

    Immune transfer from mother to infant via breastfeeding is a very important source of protection from early life infection. To the best of our knowledge this is the first demonstration that infection prior to pregnancy can transfer life-long cellular immunity to infants.

    The work shows that exposure to an infection before pregnancy can lead to a mother transferring long term immune benefits to her offspring. This is remarkable and adds a new dimension to our understanding of how a mother can influence our health."

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