There is no gainsaying when we say that there is no limit to whatever one can achieve irrespective of the situation. There are lots of people who were actually not favored by nature yet they could still make something good out of life regardless of their ordeal. People with "Down Syndrome" are people that are not always fully embraced by any society. Even in the most wealthiest and the most civilized society in the world, these kind of people are always a victim of prejudice and disparage. However, there are just some few who don't really give a shit about what the society calls them, they have gone extra mile to prove to the world that anybody can be anything.

Ángela Bachiller—Politician

Ángela Covadonga Bachiller is a Spanish city councillor for Valladolid and a member of the People's Party. She became Spain's first city councillor with Down syndrome, sworn in on 29 July 2013.

Collette Divitto—Entrepreneur

Anyone can be an entrepreneur and Collette Divitto is quite conscious of that fact. She graduated form Clemson University California and when she couldn't get a job in Cooperate America, she took another route and became an entrepreneur. She is actually the founder of Colletty’s Cookies, a restaurant based in Boston Massachusetts.

Jamie Brewer—Actress

This is quite the most popular person on this list. Jamie Brewer born in February 5th 1985 is an American actress and model who is best known for her roles in the FX horror anthology television series American Horror Story. She wasn't internationally recognized until after ten years of relentless effort in acting.

Judith Scott—Sculptor

Judith Scott was born on May 1st 1943 in Cincinnati Ohio, United States. She was a twin but unlike her fraternal twin sister Joyce, she had a Down Syndrome. Although she died in 2005 at the age of 62 but she was actually a renowned sculptor in the whole of United States. 

Sujeet Desai—Musician

Sujeet Desai is a musician from Buffalo, New York who graduated from Berkshire Hills Music Academy in South Hadley, Massachusetts. He is an accomplished musician born with Down syndrome. Sujeet has mastered seven instruments: Bb and bass clarinet, alto saxophone, violin, piano, trumpet, and drums. He has several awards to his name including a number of Olympic medals.

Karen Gaffney—Athlete

Karen Gaffney is the president of the Karen Gaffney Foundation, a non-profit organization headquartered in Oregon. The foundation is dedicated to championing the journey to full inclusion in families, schools, communities and the workplace for people with Down syndrome or other developmental disabilities. Karen Gaffney is currently a professional swimmer with several Olympics gold medals. 

Isabella Springmuhl Tejada—Designer

Isabella Springmuhl Tejada was born on October 23 1996 in Guatemala city, Guatemala. She is actually the only internationslly recognized fashion designer with a Down Syndrome. In the year 2016, she made the BBC's 100 women list, an annual collections of the most influential and inspirational women in the world.